In recent years, such devices have been widely used in the production of penicillin sodium salt and hemizygous antibiotics. In the 21st century, with the accelerating pace of GMP certification, China's pharmaceutical machinery industry has vigorously developed or copied similar imported equipment. However, due to gaps in processing accuracy and process control, domestically produced three-in-one equipment is mainly used in non-sterile APIs. Production.
Centrifugal three-in-one equipment is based on the vertical filter centrifuge to increase the function of hot air drying, filter bags or metal filter plate and other forms, the production process and tank three-in-one is basically the same, but the pumping Drying into centrifugal spin-drying can greatly reduce the production time of a single batch of materials, but due to the limit of the volume of the centrifuge bin, the single batch production capacity is limited, and it is more suitable for the production and use of sterile bulk pharmaceuticals in medium and small batches. Because this equipment can put the bin and transmission device separately in the sterile room and outside, equipment maintenance does not need to enter the sterile room, and the production and use are very convenient. In recent years, there have been joint ventures in the domestic raw material medicine industry to introduce such equipment. Domestically, imitation products have also been introduced in recent years.
Spray dryer for liquid material
The drying process of a spray dryer is similar to air drying. After the air is initially filtered, it is heated by the heater, and the hot air produced is filtered through several stages (selected according to drug grade), and then the air flow generated by the hot air distributor is uniformly rotated into the drying chamber on the volute passage at the top of the drying chamber. The material is filtered through centrifugal atomizer discs or pressure nozzles to produce a dispersed, fine material mist. The material mist is in contact with the swirling hot air and the moisture rapidly evaporates. The material is dried in a very short time.
This equipment is suitable for the drying of liquid materials with good fluidity such as solution, emulsion, suspension, paste, etc. Now it can be used for the drying of streptomycin, gentamycin, and various biological extracts produced by API industry. This device.
Boiling bed CIP and SIP
In the ebullating bed, the medicine is added from the upper part of the bed during the drying process. The hot air is blown in from the bottom and comes into contact with the material of a certain material thickness through the porous distribution plate. The material is in a fluidized and boiling state, and it is turned upside down and mixed in the air flow. With collision, large contact area between gas and solid, intense heat and mass transfer, greatly improve the drying speed and drying efficiency, is an ideal drying equipment. For some of the more humid materials can be dried once to achieve the required moisture index. Fluidized boiling thermal efficiency. Residence time can be adjusted to easily obtain a low moisture product. Size particles can be graded on the bed surface, coarse particles can be discharged from the bed, and fine powder discharged from the dust collector. Some materials, bag dusting can be done in the host (built-in type), saving space, simple structure, less investment.
This equipment is suitable for the drying of powder, granules, and silk and strip materials. The equipment is fully enclosed and can be used for CIP and SIP. It is widely used in the production of antibiotics and semi-synthetic antibiotics in the pharmaceutical industry.
Fluidized bed Thermal efficiency is high and there are no dead ends Fluidized bed is divided into ordinary fluidized bed and vibrated fluidized bed. Drug drying is affected by fluidity and most of them are vibrated fluidized bed. The dryer is excited by the vibration motor to make the machine vibrate. The material leaps forward under the exciting force in a given direction. At the same time, the hot air at the bottom of the bed makes the material in a fluidized state, and the material particles are in full contact with the hot air and violently transmitted. Heat mass transfer process, the highest thermal efficiency at this time. The upper chamber is in a state of slight negative pressure, the humid air is led by the induced draft fan, and the dry material is discharged from the discharge outlet, so as to achieve an ideal drying effect.
The equipment is fluidized evenly, with no dead angle, even temperature distribution, and high thermal efficiency. It is suitable for the drying of granules, powders, bars and filaments, and can be used for pharmaceutical intermediates such as starch, glucose and many high-volume production.
Freeze Dryer Add Mixer to Ensure Uniformity Vacuum Freeze Dryer is suitable for the drying of heat-sensitive or easily oxidized chemicals, commonly known as lyophilizer, mainly including lyophilization box, vacuum system, heating system and refrigeration system. According to the shelf area can be divided into small experimental freeze dryer, medium production freeze dryer, large industrial production freeze dryer. Drying of APIs and preparations There are many applications of freeze dryers. The main requirements are its high reliability and complete sterilization function. The temperature difference between the same shelf and the slab is not more than 1.5°C, which means that the flatness of the shelf must be better.
When using this equipment to dry raw materials, in order to ensure the homogeneity of the product, it is best to add a powder mixer. Ampicillin, a large number of blood products, artificial culture drugs, antibodies, vaccines, etc. are mostly used freeze dryers.
Centrifugal three-in-one equipment is based on the vertical filter centrifuge to increase the function of hot air drying, filter bags or metal filter plate and other forms, the production process and tank three-in-one is basically the same, but the pumping Drying into centrifugal spin-drying can greatly reduce the production time of a single batch of materials, but due to the limit of the volume of the centrifuge bin, the single batch production capacity is limited, and it is more suitable for the production and use of sterile bulk pharmaceuticals in medium and small batches. Because this equipment can put the bin and transmission device separately in the sterile room and outside, equipment maintenance does not need to enter the sterile room, and the production and use are very convenient. In recent years, there have been joint ventures in the domestic raw material medicine industry to introduce such equipment. Domestically, imitation products have also been introduced in recent years.
Spray dryer for liquid material
The drying process of a spray dryer is similar to air drying. After the air is initially filtered, it is heated by the heater, and the hot air produced is filtered through several stages (selected according to drug grade), and then the air flow generated by the hot air distributor is uniformly rotated into the drying chamber on the volute passage at the top of the drying chamber. The material is filtered through centrifugal atomizer discs or pressure nozzles to produce a dispersed, fine material mist. The material mist is in contact with the swirling hot air and the moisture rapidly evaporates. The material is dried in a very short time.
This equipment is suitable for the drying of liquid materials with good fluidity such as solution, emulsion, suspension, paste, etc. Now it can be used for the drying of streptomycin, gentamycin, and various biological extracts produced by API industry. This device.
Boiling bed CIP and SIP
In the ebullating bed, the medicine is added from the upper part of the bed during the drying process. The hot air is blown in from the bottom and comes into contact with the material of a certain material thickness through the porous distribution plate. The material is in a fluidized and boiling state, and it is turned upside down and mixed in the air flow. With collision, large contact area between gas and solid, intense heat and mass transfer, greatly improve the drying speed and drying efficiency, is an ideal drying equipment. For some of the more humid materials can be dried once to achieve the required moisture index. Fluidized boiling thermal efficiency. Residence time can be adjusted to easily obtain a low moisture product. Size particles can be graded on the bed surface, coarse particles can be discharged from the bed, and fine powder discharged from the dust collector. Some materials, bag dusting can be done in the host (built-in type), saving space, simple structure, less investment.
This equipment is suitable for the drying of powder, granules, and silk and strip materials. The equipment is fully enclosed and can be used for CIP and SIP. It is widely used in the production of antibiotics and semi-synthetic antibiotics in the pharmaceutical industry.
Fluidized bed Thermal efficiency is high and there are no dead ends Fluidized bed is divided into ordinary fluidized bed and vibrated fluidized bed. Drug drying is affected by fluidity and most of them are vibrated fluidized bed. The dryer is excited by the vibration motor to make the machine vibrate. The material leaps forward under the exciting force in a given direction. At the same time, the hot air at the bottom of the bed makes the material in a fluidized state, and the material particles are in full contact with the hot air and violently transmitted. Heat mass transfer process, the highest thermal efficiency at this time. The upper chamber is in a state of slight negative pressure, the humid air is led by the induced draft fan, and the dry material is discharged from the discharge outlet, so as to achieve an ideal drying effect.
The equipment is fluidized evenly, with no dead angle, even temperature distribution, and high thermal efficiency. It is suitable for the drying of granules, powders, bars and filaments, and can be used for pharmaceutical intermediates such as starch, glucose and many high-volume production.
Freeze Dryer Add Mixer to Ensure Uniformity Vacuum Freeze Dryer is suitable for the drying of heat-sensitive or easily oxidized chemicals, commonly known as lyophilizer, mainly including lyophilization box, vacuum system, heating system and refrigeration system. According to the shelf area can be divided into small experimental freeze dryer, medium production freeze dryer, large industrial production freeze dryer. Drying of APIs and preparations There are many applications of freeze dryers. The main requirements are its high reliability and complete sterilization function. The temperature difference between the same shelf and the slab is not more than 1.5°C, which means that the flatness of the shelf must be better.
When using this equipment to dry raw materials, in order to ensure the homogeneity of the product, it is best to add a powder mixer. Ampicillin, a large number of blood products, artificial culture drugs, antibodies, vaccines, etc. are mostly used freeze dryers.
Ceramic Sintering Furnace,Electronic Ceramic Sintering Furnace,High Temperature Heat Treatment Furnace,Ceramic Atomizing Core Sintering Furnace
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